Whilst minimal-depend MBL almost never progresses to CLL, substantial-depend MBL progresses to CLL requiring therapy in a rate of 1% to two% a year. Significant-depend MBL is distinguished from Rai 0 CLL based upon whether or not the B-mobile depend is higher than or underneath 5 × 109/L. Whilst people today with both superior-depend MBL and CLL R